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KMID : 1004620140200030326
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Clinical Nursing Research
2014 Volume.20 No. 3 p.326 ~ p.336
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Comparison of Heparin Solution and 0.9% Normal Saline Solution Flushing to Secure the Patency of NonTunneled Central Venous Catheters
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Kim Ji-Hye
Seo Eun-Ji
Park Hee-Jung
Kim Si-Hyeon
Min Ja
Park Jeong-Yun
Kim Song-Cheol
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Abstract
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Purpose: The purpose of this study was to compare the effectiveness of heparin and 0.9% normal saline solution
flushing for maintaining patency of nontunneled central venous catheters in patients with surgery.
Methods: A randomized controlled clinical trial was performed. Fiftyeight patients were prospectively enrolled and
fifty-four patients were completed the study. The heparin group consisted of 30 patients given 100u/ml diluted heparin flushing and the normal saline group consisted of 24 patients with 0.9% sodium chloride flushing.
Results: There was no significantly difference in occlusion between the heparin group and the normal saline group in nontunneled central venous catheters’ occlusion. Also there was no difference between these two groups in catheterrelated infections.
Conclusion: Flushing with 0.9% normal saline is as effective as flushing with heparin solution in maintaining the patency of nontunneled central venous catheters. In this study, however, the duration of central line use was short and the infection occurrence was little. Further studies are warranted with a larger sample size at multiple centers.
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KEYWORD
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Central venous catheters, Heparin, Sodium chloride, Catheter obstruction, Infection
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